The crash happened around 3 p.m., forcing Ontario Provincial Police to close the highway's westbound lanes from Joyceville Road to Highway 15.
Major vehicle pile-up on 401 in Kingston — Kingston News
In a statement to CBC News, Kingston General Hospital said between 15 and 20 people had arrived at the hospital, "most of whom have non-life-threatening injuries."
Frontenac OPP Const. Curtis Dick told CBC News that one person had died in the pileup, which involved at least one tractor-trailer.
Kingston Transit also responded with several buses to assist in sheltering dozens of affected travellers in the white-out conditions.
Stranded passengers would be taken to warming centres in Kingston, Dick said. The highway would not be reopening anytime soon, he added.
The Kingston area is currently under a winter travel advisory, with as much as 15 centimetres of snow expected to fall along the shores of Lake Ontario by Sunday evening.
There were reports of heavy snow in the area at the time of the crash, said OPP spokesperson Bill Dickson.
Kingston police were also dealing with a gas leak after an afternoon collision at Princess and Macdonnell streets, a crash that Sgt. Steve Koopman said was also likely weather-related.
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KINGSTON — One person has died and multiple people have been injured following a crash involving about 30 vehicles that shut down the westbound lanes of Highway 401 in Kingston Sunday afternoon.
UPDATE ROAD CLOSURE: #Hwy401 WB at Joyceville #ygk – Highway is now CLOSED following collision. Traffic diverting off at Joyceville Rd. ^jt
Kingston is under a winter weather travel advisory with up to 15 cm of snow expected by Sunday night.